Friday, August 3, 2012

State Radio Systems Upgrade Could Cut Regional Dispatchers Out ...

Stephen Betts, Bangor Daily News (Maine) Staff

Regional dispatchers are worried they will be out of the communications loop after state public safety departments such as state police, warden and forestry services and marine patrol upgrade their radio communication systems from analog to digital.

The upgrade for the state departments, known as the MS Comnet project, carries a price tag of about $55 million, and when it is done will allow state public safety officials from Kittery to Madawaska to communicate via radio, according to Jim Ryan, executive director for Penobscot County Regional Communications.

But regional dispatch centers will need to upgrade to digital systems to hear the new transmissions.

And Ryan said when the state originally went out to sell the upgrade to legislators and community officials they proposed an analog system. In anticipation, Penobscot County purchased analog equipment to coordinate with the state, the state announced they were going digital, he said.

He said it would cost $500,000 for Penobscot County to acquire new equipment that would be compatible with the state system.

Knox County Regional Communications Center Director Linwood Lothrop also expressed similar concerns about the new state radio system and said it would make it more difficult for county dispatches to keep track of what is going on with state units.

Lt. Col. Raymond Bessette of the Maine State Police said the digital upgrade has been necessary for years to meet capacity needs for state emergency personnel.

The upgrade will allow many more radio frequencies that will serve emergency responders when they respond to escalating situations.

Bessette said the state asked the vendor for the radio upgrade to allow its county and municipal partners to hear the state radio communications and that will be done.

The public will also be able to follow the radio communications, although they will need to purchase digital scanners, he said.

Copyright ? 2012 LexisNexis, a division of Reed Elsevier Inc. All Rights Reserved.

Source: http://psc.apcointl.org/2012/08/02/state-radio-systems-upgrade-could-cut-regional-dispatchers-out-of-the-loop/

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Thursday, August 2, 2012

New Therapeutic Target for Aggressive Breast Cancer | Medical ...


(Ivanhoe Newswire) ? A new therapeutic target for advanced breast cancer has shown promising results in mouse models, according to a study performed by Western University.

Lynne-Marie Postovit of Western?s Schulich School of Medicine and Dentistry analyzed a protein called Nodal, which is primarily found in embryonic or stem cells. She discovered high levels of Nodal in aggressive breast cancer tumors. The protein was found to promote vascularization in the tumor, providing nutrients and oxygen to help it grow and spread.

"We have determined that breast cancers, specifically those very aggressive, invasive breast cancers that spread, express an embryonic protein called Nodal and the expression of this protein is correlated with more blood vessels in the tumor. Blood vessels, many studies have shown, help to allow tumors to grow but also to spread throughout the body," Postovit was quoted as saying. "In addition, we have shown that if we can target this embryonic protein, we can cause the blood vessels to collapse within the tumor, leading to decreased oxygen levels and tumor cell death. When tumors lack oxygen and nutrients they become what we call necrotic."

For the study, researchers designed mouse models to develop breast cancer tumors. Next, using a genetic modification, the researchers turned off the expression of Nodal. After doing so, the blood vessels in the tumor appeared to collapse and the tumor became less aggressive. Because Nodal is on the outside of the cell, it can be easily targeted by a number of mechanisms like antibodies. Patients could potentially have better outcomes because Nodal isn?t expressed in normal body tissue, thus making it possible to solely target the cancer.

"Ultimately it would be nice to target Nodal in patients who already have quite advanced, well-vascularized tumors as a new option for therapy," Daniela Quail, first author on the research and a PhD candidate in the Postovit lab, was quoted as saying. "Currently, patients like this don't have many options."

"In Canada, breast cancer continues to be one of the most common forms of cancer in women. Although new treatment methods have improved outcomes, a significant number of women still die from this disease", Dr. Morag Park, Scientific Director of the Canadian Institutes of Health Research, was quoted as saying. "Research advancements, such as Dr. Postovit's, have contributed and will continue to contribute to the improvements around our understanding of cancer progression and treatment. I congratulate Dr. Postovit and the team on this advancement and its significant contribution to this field."

Source: Cancer Research, July 2012

Source: http://www.ivanhoe.com/channels/p_channelstory.cfm?storyid=29835

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Fed wraps up meeting as markets await action

WASHINGTON (AP) ? The Federal Reserve concludes its two-day policy meeting Wednesday with a big question looming: Will it take some new action to jolt the U.S. economy out of its slump?

Investors are hoping the Fed will announce another round of bond purchases, known as quantitative easing. The goal is to lower long-term interest rates and encourage more borrowing and spending.

But economists say the Fed is likely to hold off until September to wait and see if job growth and consumer spending to pick up.

U.S. growth slowed to an annual rate of just 1.5 percent from April through June, down from the 2 percent pace in the first quarter. And consumers spent no more in June than they did in May, even though their income grew by 0.5 percent.

Fed officials have signaled their concern about weakening job growth and consumer spending, which have brought the economy closer to a standstill. And Federal Reserve Chairman Ben Bernanke has said the Fed is prepared to take further action if unemployment stays high.

"The weakness of the economy will force them to act," said David Jones, chief economist at DMJ Advisors. "Bernanke has been really straightforward. He has said if the recovery loses momentum and labor market conditions are not improving, we will get more easing."

The Fed could announce an interim step Wednesday. One possibility is it could extend a plan to keep its benchmark interest rate near zero, from late-2014 until to mid-2015. The goal of such a move would be to assure consumers and businesses that they will be able to borrow cheaply well into the future. But it also signals that the Fed expects the economy to stay weak for some time.

The meeting is one of three big events this week that investors and economists will pay close attention to. The European Central Bank meets on Thursday, and the U.S. Labor Department releases the July jobs report on Friday.

Economists forecast that U.S. employers added 100,000 jobs in July. That would be only slightly better than the 75,000 a month from April through June and still down from a healthy 226,000 average in the first three months of the year. The unemployment rate is expected to stay at 8.2 percent.

Worries have also intensified about Europe's debt crisis and whether the U.S. economy will fall off a "fiscal cliff" at the end of the year. That's when tax increases and deep spending cuts will take effect unless Congress reaches a budget deal. A recession could follow, Bernanke has warned.

The Fed has already pursued two rounds of purchases of Treasury bonds and mortgage-backed securities.

The Fed has also extended a program called Operation Twist. Under this program, the Fed sells short-term Treasurys and buys longer-term Treasurys. The goal is to lower longer-term interest rates.

Even if the Fed launched a third round of bond purchases, few think that further lowering long-term rates would provide much benefit to the U.S. economy. Most businesses and consumers who aren't borrowing now aren't likely to change their minds if rates slipped a bit more.

The yield on the benchmark 10-year Treasury note is already just above its record low of 1.39 percent, which it touched last week. The national average rate for a new-car loan barely tops 3 percent. And the average on a 30-year fixed-rate mortgage fell below 3.5 percent last week for the first time on records dating back 60 years.

Some regional Fed bank presidents have expressed concern that expanding the Fed's investment portfolio beyond its current record $2.9 trillion to try to lower rates more would heighten the risk of high inflation later.

"Various Fed officials have made it pretty clear they want to do something, but they still have a lot of discussion to go through before they get to a decision," said Diane Swonk, chief economist at Mesirow Financial in Chicago. "How do you get the biggest bang for the dollar when the ammunition you have left is limited?"

Some analysts have also suggested that the Fed might be reluctant to act aggressively as the November election nears, out of concern it could be seen as affecting the vote.

If the Fed does announce further bond buying, some think the purchases might be divided between Treasurys and mortgage-backed securities. Though at record lows, mortgage rates are still higher than rates on some other loans. Further declines in those rates could help fuel home sales.

Source: http://news.yahoo.com/fed-wraps-meeting-markets-await-action-070609465--finance.html

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DOG AND CAT HEALTHCARE | Lincoln County View

Karen Miller

?

???? Do you know that you should visit your doctor at least yearly to have a physical exam? Well, the same applies to your pet. Dogs and cats should be examined at least yearly by their veterinarian. Pets age faster than we do and their lifespans are shorter than ours. For example, the larger breed a dog is, the shorter their lifespan. An 8 year old Great Dane is not the same age in human years as an 8 year old toy Poodle. As dogs and cats get older, they should be examined at least twice yearly because their health status can change rapidly.

During a physical exam, your veterinarian is checking your pet?s eyes, ears, teeth and gums, skin, joints, abdomen, external lymph nodes, and listening to their heart and lungs with a stethoscope. During your visit, your vet can administer the appropriate vaccines for your pet. Yes, vaccines are still needed by dogs and cats. These vaccines protect your pet from various contagious diseases that include distemper, parvovirus, kennel cough, leptospirosis, rabies, feline leukemia, feline rhinotracheitis, feline panleukopenia, feline calicivirus, and feline chlamydiosis. Your veterinarian can explain what each of these diseases is.? Rabies vaccination is required by state law- even if your dog or cat is a ?totally inside pet?. These diseases are still out there. Did you know that some N.C. animal shelters have been temporarily closed within the last year due to outbreaks of parvo and distemper? Did you also know that there is a canine influenza virus and a vaccine for it? Your veterinarian is the best source of information about the healthcare of your pet. Vets are here to educate you and to help you take care of your pet. Feel free to ask your vets and their staff questions and voice concerns about your pet and be an active participant in the healthcare of your pet.

Heartworm disease is very common in our area and a yearly heartworm test should be part of your dog?s exam. Heartworms are transmitted by mosquitoes and are completely preventable with either monthly medication or, for dogs, a 6 month injectable medication. Did you know that cats can also get heartworms and there is prevention available for them too?

Your dog and cat should also be tested at least yearly for intestinal parasites. Heartworm preventions can also deworm for certain, but not all, intestinal parasites. Some of the intestinal parasites that dogs and cats can have are zoonotic, which means that people can get them too.

Flea and tick medications are important for your pet also. Fleas and ticks can both carry diseases, more than just Rocky Mountain Spotted Fever and Lyme disease. Some over the counter medicines work, some don?t and you don?t have your veterinarian to advise you with those. Some of those products can be toxic, especially to your cat. Your vet can advise you on your flea and tick options and what is the best medicine for your pet. Did you know there is now a pill available for dogs that is heartworm and flea medication in one?

Remember that your veterinarian is the best advocate for your pet?s healthcare and wants to help you take the best care of them possible. Don?t hesitate to call your vet with your questions or concerns. Together you can help your pet live a longer, healthier, and happier life.

?

Karen Miller, DVM

Veterinarian and owner ofLincolntonAnimalHospital

Source: http://lincolncountyview.com/?p=29735

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Wednesday, August 1, 2012

just the Research - Just Drinks

Here's a run-down of some of the top research reports currently available in the just-drinks research store:

WINE AND CHAMPAGNE

The key factors driving the sparkling wine market are analysed and presented in this study, along with over 40 data tables covering the world's major markets by retail value, plus top brands and owner companies' volumes by market with year-on-year trends. All data includes just-released 2011 actual market volumes.

This latest edition of the global market review of Champagne provides an overview of the category, for all major markets plus the emerging markets of Brazil, Russia, India and China. Data is provided for Champagne shipments to main markets (volume and value) from 2006 to 2011 and predictions of shipments from 2012 to 2016.

ALCOHOLIC BEVERAGES

There were 28,541 respondents to this 2011 global consumer survey, which took place in 20 markets. There are four 'dashboards' in this interactive model, allowing you to select your preferred analysis: by individual market; global overview; gender comparison, or age comparison.

This comprehensive report examines the South African consumption market trends (2007-2011) as well as geo-demographic trends among the different alcoholic beverage categories, including local consumer/market trends, and detailed consumer geo-demographic profiling of several categories of alcoholic beverages.

FUNCTIONAL

Although functional food and drinks are gaining in popularity, many consumers are interested in the benefits but not yet purchasing the products. Use this interactive model to discover where there is such latent interest. How do different demographics vary in what they are interested in and how many need an extra reason to buy.

Use this report to identify the size of the cognitive alertness/energizing and relaxation markets across 20 countries and growth prospects up until 2015. Evaluate the potential impact on consumer demand of marketing and product development through utilising consumer, product and market insight.?

SPIRITS

The IWSR Insight Report distils the latest trends observed in over 115 countries following the IWSR's unique interviews with over 1,200 local companies. It focuses on written insights and gives concrete examples and explanations behind the latest trends. The report offers unique observations about every important alcoholic drinks category in all corners of the world.

Cacha?a has been widely tipped as the next big international spirits category. Much of that enthusiasm is based on potential, rather than actual, international performance to date. With Brazil scheduled to host both the Football World Cup in 2014 and the Summer Olympics in Rio in 2016, there has possibly never been a better time to build global awareness around the national spirit.

Source: http://www.just-drinks.com/news/just-the-research_id107740.aspx

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Lixisenatide ? Comprehensive patent search - Market Research News

Imagine having your own team of pharmaceutical patent experts, at a fraction of the cost and without the wait.?

Used by the worlds leading generic pharmaceutical companies and legal teams, Pipeline Developer minimises the risk of wasted developments or legal action, by providing you with nothing less than the very best in comprehensive patent information. Searched and analysed by highly trained, dedicated staff using sophisticated searching techniques, Pipeline Developer delivers results you can rely on. And that means your staff can concentrate on how the patent landscape affects your business, rather than trying to source reliable patent information.

Pipeline Developer features:?

Comprehensive patent searching, covering the world?s key territories (see ?search coverage? below)
Identifies patents covering molecule, formulation, process, use, combination and assay techniques (see ?Patent Categories Identified?below)
Patent identification, categorisation and interpretation
Grouped by patent family and assigned to development categories based on Interpretation of key aspects of the patent claims
Manual filtration of patents not relevant to generic development
Updated on a monthly basis, including changes to patent families, statuses, and litigation
Enables fast analysis and verification by hyper-linking to crucial patent documents and national registers

Patent Categories Identified:?

Molecular Form

Molecule Patents
Salts, Hydrates & Solvates
Polymorphic Forms
Other Molecular Forms

Active Ingredient Preparation

Intermediates & Preparation Thereof
Final Synthetic Stages
Complete Synthesis
Purification Methods
Fermentation Methods
Biotechnology

Formulations & Methods Thereof

General Formulations & Methods
Injectable Formulations
Oral Formulations
Other Administration-Specific Formulations
Excipients, Kits & Packaging

Related Medical Use & Administration

New Use Related to Main Indication
Dosing Regimen/Administration Conditions

Active Ingredient Combinations

Novel Combinations
Use of Combinations
Dosing Regimen & Administration Conditions for Combinations

Analytical Methods

Assaying Methods
Methods of Determining Patient Suitability

Search coverage:

Clicking on a patent family displays detailed information on the ?Core? and ?Non-Core? ?Patent Family Equivalents?. ?Core Patent Family Equivalents? are equivalent patents from territories that are individually verified and monitored for changes, including British, German, Spanish, French, US, Canadian, Australian, European, and PCT patents. Statuses are also monitored and updated. ?Extended Patent Family Equivalents? are equivalent patents found through the INPADOC database, increasing the search coverage to 70 countries.

Patent and national register access:

Clicking on a listed patent/application number or text or image link will launch a pop-up window containing an image of the patent, enabling easy analysis of the patent documents. Clicking on a register link launches a pop-up window with the patent office register extract for that patent. This allows investigation into the examination status of a pending patent, opposition of a granted patent and/or payment of maintenance fees. Please note that no extra charges apply to accessing or downloading documents of any kind.

Litigation alerts:

Informing you of developments in court, litigation alerts can also be accessed by clicking on the litigation symbol next to the status, with links to judgements where available.

Updating:

To take the time and hassle out of monitoring and updating a large number of patents, all Pipeline Developer reporting is updated on a monthly basis. Convenient change flags identify new patent families, new patent family members, changes in statuses and litigation alerts.?

Legal status and transaction history:

You can also find legal status and transaction history for ?Extended Patent Family Equivalents? by clicking on the INPADOC Family/Legal Status button for 65 additional territories.

Reporting and access:

All data can be exported into Microsoft Excel and print friendly versions for ease of data manipulation and reporting. Company details are confidential and all data is SSL secure. Five users per company are permitted and access levels are controlled by a nominated ?company administrator?.

Pipeline Developer is just one of the benchmark products from GenericsWeb?s Pipeline Patent Intelligence product suite.

Original Post Lixisenatide ? Comprehensive patent search source Researchmoz Market Research
GenericsWeb Reports

Source: http://www.healthcarestoreonline.com/wiki/lixisenatide-comprehensive-patent-search

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India's blackouts shine light on broken power sector

REUTERS (Reuters) - As India's power minister stood up to address parliament one day last May, the chamber was plunged into darkness and a roar of laughter went up.

Rolling power cuts are part of daily life in India, where energy production falls far short of the demands of a fast-growing economy and an increasingly affluent population, but blackouts for two days this week across a vast swathe of the country were no laughing matter.

Three of India's five transmission grids collapsed on Tuesday, cutting power to states where some 670 million people live, more than half of the country's population. That blackout, one of the world's worst, followed a similar breakdown across the north the previous day.

It is not clear what sparked the massive failures.

The central government has accused state governments of taking more electricity from the grids than their allotted quotas, and some have blamed disappointing monsoon rains for a surge in power demand from farmers struggling to irrigate their land.

However, deep-seated problems spanning the generation of power to its distribution mean a repeat of this week's fiasco cannot be ruled out.

"So many things have been ignored. So many things have not been done. It is lack of initiative and wrong initiative, wrong policy and no policy," said Suresh Prabhu, who was power minister in a previous government led by the main opposition party.

Prabhu said the power sector was in complete chaos and risked collapse if no action was taken quickly.

POWER PLANT DELAYS

India has installed power capacity of 205,000 megawatts (MW), about 35 percent more than it had five years ago, thanks to an aggressive drive by the government to add more.

However, that is still only about a fifth of China's capacity, and so - even though one third of Indians are not even connected to a power grid - there is a gap between supply and demand, with the peak-hour deficit reaching about 10 percent.

Efforts to accelerate the pace of capacity addition have been thwarted by hurdles standing in the way of land acquisition and clearances for power projects, including regulatory delays and environmental concerns.

Government data shows that the average delay for construction of thermal power projects is running at 15 months, but some have been on the drawing board for years.

Take the case of billionaire Anil Ambani's plan to set up a 7,480 MW plant at Dadri in the northern state of Uttar Pradesh. A decade after the project was announced it is still not operational after protests by farmers over land acquisition and a legal challenge that is still pending in the Supreme Court.

Coal and natural gas shortages have crimped the rollout of new plants and left many existing units running below potential, where in all some 15,000 MW of capacity are lying idle.

Ambani's Reliance Power has built the first phase of a $1.8 billion plant in the southern state of Andhra Pradesh, sourcing state-of-the-art equipment from General Electric Co, but it doesn't have the gas to start it up.

The fuel shortage is acute when it comes to coal, which accounts for two-thirds of the country's power generation.

India has about 10 percent of the world's coal reserves but output by the near-monopoly Coal India has stagnated, importing coal is far more costly and a lack of rail capacity from ports has held up supplies. Many power plants have less than seven days' of coal stocks, a level seen as critical to continuous operation.

"Coal India has enough reserves. But evacuation (transportation) is the main problem," said a senior coal ministry official. He said Coal India had set aside $900 million to lay train tracks in the next five years but the railway ministry had not responded to the plan.

DISTRIBUTION COMPANIES IN TROUBLE

While generation capacity has increased, renovation of the transmission network has not kept pace, which means that about one-third of production is lost at this stage.

"A lot of the transmission network is not old," said Kameswara Rao, leader for power and mining at Price Waterhouse Coopers India. "We are running but the treadmill is even faster."

Perhaps the biggest challenge, though, is the health of decrepit distribution companies that depend on subsidies and face huge losses from low tariffs and rampant power theft. Together, they are now saddled with debt worth some $35 billion and are increasingly unable to pay for new supplies.

"Generation capacity will only get financed if the financiers feel that the generators are selling power to distributors who are financially capable of paying for it," Planning Commission deputy chairman Montek Singh Ahluwalia said recently in defense of a government plan to bail out the mostly state-owned distribution companies.

Populist-inclined state governments have made it difficult for distributors to set cost-reflective tariffs. However, with bank loans drying up, many distributors have been forced to raise tariffs sharply over the past six months.

To be fair, there have been many steps to reform the power sector over the past decade.

The generation, transmission and distribution segments of the industry have been separated to allow each to work on its own, and private investors have been drawn into generation in particular, now accounting for about one quarter of capacity.

However, more sector reform is unlikely to come quickly from a government that appears to feel it has much to be proud of.

Sushilkumar Shinde, who was promoted from power minister to interior minister even as the country reeled from Tuesday's blackout, told a news channel the next day: "I rate myself as an excellent power minister."

(Additional reporting by Rosemary Arackaparambil, Malini Menon and Ketan Bondre; Editing by Frank Jack Daniel and Robert Birsel)

Source: http://news.yahoo.com/indias-blackouts-shine-light-broken-power-sector-123427072--sector.html

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